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The effect of duodenal content is stronger than gastric juice.It may play an important role in tumourgenesis of gastroesophageal reflux disease. 結論：胃液及十二指腸內容物反流可通過改變抑癌基因的蛋白表達而影響致癌劑甲基戊基亞硝胺誘發大鼠食琯腫瘤的作用，其中十二指腸內容物的作用較胃液更強。